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Related Experiment Video

Updated: Aug 17, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Neglected no more: B cell-mediated anti-tumor immunity.

Jose R Conejo-Garcia¹, Subir Biswas¹, Ricardo Chaurio¹

¹Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.

Seminars in Immunology

|December 17, 2022

Summary

Immuno-oncology is rethinking the role of B cells and antibodies in cancer. Tertiary lymphoid structures are key for effective anti-tumor immunity and immunotherapy response.

Keywords:

B cell Cancer antibodies Plasma cell Tertiary lymphoid structure Tumor immunology

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Published on: October 16, 2018

Area of Science:

Immunology
Oncology
Cancer Research

Background:

Traditional immuno-oncology focused on T cell responses, viewing humoral immunity as tumor-promoting.
This perspective was largely based on mouse models, which don't fully reflect human cancer antibody responses.
Recent human cancer studies highlight the positive impact of B cell responses, often alongside T cell activity.

Purpose of the Study:

To re-evaluate the role of humoral immunity in anti-tumor responses.
To discuss the significance of B cell responses and tertiary lymphoid structures in cancer immunity.
To explore interventions for enhancing tertiary lymphoid structures in tumors.

Main Methods:

Review of recent discoveries in immuno-oncology and cancer immunology.
Analysis of the coordinated action of T and B cell responses in human cancers.
Discussion of the role and formation of tertiary lymphoid structures.

Main Results:

B cell responses are increasingly associated with better patient outcomes in human cancers.
Tertiary lymphoid structures, sites of B cell activity and immune cell interaction, correlate with improved immunotherapy responses.
Coordination between humoral and cellular immunity is crucial for effective anti-tumor pressure.

Conclusions:

A coordinated humoral and cellular immune response is essential for anti-tumor immunity.
Tertiary lymphoid structures play a critical role in anti-tumor immunity and immunotherapy efficacy.
Further research into interventions that promote tertiary lymphoid structures is warranted for improving cancer treatment.