Related Experiment Video
Updated: Aug 17, 2025
07:37
Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
23.6K
Metabolic changes after surgical fat removal: A dose-response meta-analysis
Saif Badran1, Abdella M Habib2, Ghanem Aljassem3
1Division of Plastic and Reconstructive Surgery, Washington University, St. Louis, MO, USA; Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar.
Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
|December 17, 2022
Summary
Surgical fat removal offers short-term metabolic improvements, but only insulin sensitivity benefits persist long-term. This contrasts with bariatric surgery
Area of Science:
- Metabolic Surgery
- Body Composition
- Endocrinology
Background:
- Bariatric surgery improves obesity-related metabolic issues.
- Surgical fat removal is typically viewed as cosmetic.
- This study investigates if fat removal offers lasting metabolic benefits.
Approach:
- Systematic review and meta-regression of 22 studies (493 participants).
- Searched PubMed, Embase, and Scopus for metabolic marker expression.
- Assessed study quality using the MethodologicAl STandard for Epidemiological Research scale.
Key Points:
- Insulin sensitivity improved up to 180 days post-surgery.
- Peak benefits (reduced BMI, fat mass, leptin, TNF-α, cholesterol, blood pressure) occurred at 50 days.
- Most benefits returned to baseline by 180 days; HDL levels decreased below baseline.
Conclusions:
- Surgical fat removal provides transient metabolic advantages.
- Only enhanced insulin sensitivity demonstrates durability beyond six months.
- Distinguishes fat removal from bariatric surgery's metabolic impact.
