Impact of COVID-19 on Patients Hospitalized With Deep Vein Thrombosis and/or Pulmonary Embolism: A Nationwide

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Adrija Hajra1, Akshay Goel2, Aaqib H Malik2

  • 1Department of Internal Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY.

Current Problems in Cardiology
|December 17, 2022
PubMed

Insights

Coronavirus disease 2019 (COVID-19) patients with deep vein thrombosis (DVT) and pulmonary embolism (PE) had higher in-hospital mortality than flu patients. Risk factors for COVID-19-associated DVT/PE mortality include older age and certain chronic conditions.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pulmonology

Background:

  • Coronavirus disease 2019 (COVID-19) is linked to an increased risk of venous thromboembolism, including deep vein thrombosis (DVT) and pulmonary embolism (PE).
  • Understanding the comparative in-hospital outcomes of patients with DVT/PE and concurrent COVID-19 versus flu is crucial for clinical management.

Purpose of the Study:

  • To compare in-hospital outcomes for patients diagnosed with DVT and/or PE who have concurrent COVID-19 infection versus those with concurrent flu infection.

Main Methods:

  • Analysis of the National Inpatient Sample (2019-2020) to identify adult hospitalizations with DVT and/or PE.
  • Stratification of patients based on concomitant COVID-19 or flu infection.
  • 1:1 propensity score matching to compare outcomes between the two groups.

Main Results:

  • Higher incidence of cardiac arrest and inpatient mortality observed in the COVID-19 group compared to the flu group.
  • Increased incidence of cardiogenic shock noted in the flu group.
  • Independent predictors of mortality in COVID-19 patients with DVT/PE included advanced age, Hispanic ethnicity, diabetes, chronic kidney disease, arrhythmia, liver disease, coagulopathy, and rheumatologic diseases.

Conclusions:

  • COVID-19 patients with DVT and/or PE face a higher risk of in-hospital mortality and cardiac arrest compared to flu patients.
  • Specific demographic and comorbidity factors significantly predict mortality in COVID-19 patients with DVT/PE.

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