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Updated: Aug 17, 2025

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Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
Published on: March 28, 2025
371
Alveolar echinococcosis in immunocompromised hosts
Brice Autier1, Bruno Gottstein2, Laurence Millon3
1Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), UMR_S 1085, Rennes, France.
Summary
Alveolar echinococcosis (AE) is increasingly seen in immunocompromised patients, presenting with earlier diagnosis and atypical imaging. Serological screening before immunosuppressive therapy is recommended for those in endemic areas.
Area of Science:
- Infectious Diseases
- Parasitology
- Immunology
Background:
- Alveolar echinococcosis (AE) is caused by Echinococcus multilocularis larvae.
- AE is increasingly observed in individuals with compromised immune systems.
Purpose of the Study:
- To review the presentation of AE in immunocompromised individuals.
- To analyze AE based on the type of immune impairment.
- To propose management strategies and future research directions.
Main Methods:
- A narrative review of AE in immunocompromised patients.
- Literature search in PubMed using keywords related to AE and immunosuppression.
- Analysis of 17 publications including retrospective cohorts and case reports.
Main Results:
- AE in immunocompromised patients (AE/IS) is associated with earlier diagnosis and atypical imaging compared to immunocompetent patients.
- Solid organ transplantation (SOT), autoimmune diseases (I/AID), and malignancies are significantly associated with AE.
- Serology shows lower sensitivity in AE/IS patients.
Conclusions:
- Serological screening for AE before immunosuppressive therapy may benefit patients in endemic areas.
- Physicians should consider AE in immunocompromised patients with liver lesions.
- Further research and multinational registries are needed to improve understanding and management of AE/IS.
Keywords:
Alveolar echinococcosisCancerEchinococcus multilocularisHIVImmunosuppressive therapyMalignant haemopathyPrimary immune deficiencyTransplantationMore Related Videos
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