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Updated: Aug 17, 2025

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
Published on: January 7, 2019
Trends in the pathophysiology of Charcot neuroarthropathy
1Diabetology Department, Centre, Hopitalier Sud Francilien, Corbeil-Essonnes, France; LBEPS, Université d'Evry, IRBA, Université Paris Saclay, 91025 Evry, France.
Abstract:
The pathophysiology of Charcot neuroarthropathy (CN) includes a number of gray areas, particularly regarding the onset of inflammation which induces the disruption of the bone remodeling factor responsible for the onset of bone lysis. This clinical insight highlights a potential link between this inflammation and the rapid correction of chronic hyperglycemia (Dardari et al., 2022), which is known to be responsible for a particular type of neuropathy known as treatment-induced neuropathy of diabetes (TIND). Our description makes an additional contribution to shed light on the mysterious physiopathology of CN.
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