Related Experiment Video
Updated: Aug 17, 2025
Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
Published on: January 29, 2016
Effect of MS14® on physical activity of multiple sclerosis patients: A randomized triple-blind placebo-controlled
Hossein Rezaeizadeh1, Kourosh Gharegozli2, Seyed Masood Nabavi3
1Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Introduction:
Multiple Sclerosis (MS) is a neurological disorder with an increasing global prevalence and severe complications. MS14® is a Persian-medicine-derived natural product with herbal and marine origin which has shown beneficial effects in the management of MS complications. In this study, its effect on physical activity of MS patients was investigated.
Methods:
A triple-blind placebo-controlled clinical trial was conducted. Participants used either MS14 capsule or placebo 3 times a day for 3 weeks. At baseline and end of the study, physical activity indices were assessed using international physical activity questionnaire (IPAQ). Secondary outcome measures were Fatigue Severity Scale (FSS), timed 10 m walk, Ashworth scale, and Timed Get up and Go.
Results:
A total number of 80 MS patients completed the study. At the end of study, improvement of general physical activity (p-value=0.047) and Timed 10 m walk index (p-value=0.003) in the MS14 group was significant when compared to placebo. No serious adverse effects were observed in this study.
Conclusion:
Considering the improvement of some physical activity indices, MS14® is seems to be a safe natural product which could be considered as a supplementary treatment in MS patients. Future larger trials are suggested to further evaluate its efficacy.
Insights
MS14®, a natural product, improved physical activity and walking speed in Multiple Sclerosis (MS) patients. This study suggests MS14® is a safe supplementary treatment for MS, with no serious adverse effects observed.
Area of Science:
- Neurology
- Integrative Medicine
- Pharmacology
Background:
- Multiple Sclerosis (MS) is a progressive neurological disorder with significant global impact.
- MS complications often impair patients' quality of life and physical function.
- MS14®, a natural product derived from Persian medicine, has shown promise in managing MS symptoms.
Purpose of the Study:
- To evaluate the efficacy of MS14® in improving physical activity in patients with Multiple Sclerosis.
- To assess the safety profile of MS14® as a supplementary treatment for MS.
Main Methods:
- A triple-blind, placebo-controlled clinical trial was conducted involving 80 MS patients.
- Participants received either MS14® capsules or a placebo three times daily for three weeks.
- Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ), alongside measures like the timed 10m walk, Fatigue Severity Scale (FSS), Ashworth scale, and Timed Get up and Go.
Main Results:
- Significant improvements in general physical activity (p=0.047) and the timed 10m walk index (p=0.003) were observed in the MS14® group compared to placebo.
- No serious adverse effects were reported during the study period.
- The study demonstrated a positive impact of MS14® on specific physical function markers in MS patients.
Conclusions:
- MS14® appears to be a safe natural product for managing physical activity in Multiple Sclerosis patients.
- The observed improvements in physical activity indices suggest MS14® could serve as a beneficial adjunctive therapy.
- Further large-scale clinical trials are recommended to confirm the efficacy and long-term benefits of MS14® in MS management.
