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Heart rate fragmentation is impaired in type 2 diabetes mellitus patients

Gabriela Aguiar Mesquita Galdino1, Luiz Eduardo Virgilio Silva2, Silvia Cristina Garcia Moura-Tonello1

  • 1Cardiovascular Physical Therapy Laboratory, Department of Physical Therapy, Federal University of São Carlos, São Carlos, SP, Brazil.

Diabetes Research and Clinical Practice
|December 18, 2022
PubMed

Insights

Type 2 diabetes mellitus (T2DM) patients exhibit altered heart rate fragmentation (HRF) patterns compared to healthy individuals. HRF analysis may help detect heart rate abnormalities in men with T2DM.

Area of Science:

  • Cardiology
  • Diabetology
  • Biomedical Engineering

Background:

  • Type 2 diabetes mellitus (T2DM) is associated with cardiovascular complications.
  • Heart rate variability (HRV) is a recognized marker of autonomic dysfunction.
  • Heart rate fragmentation (HRF) offers a novel approach to analyze heart rate dynamics.

Purpose of the Study:

  • To assess heart rate fragmentation (HRF) patterns in men with type 2 diabetes mellitus (T2DM).
  • To investigate the relationship between HRF indices and established heart rate variability (HRV) parameters in T2DM patients.

Main Methods:

  • Retrospective analysis of 164 men (82 T2DM, 82 healthy), aged 47-57 years.
  • Electrocardiogram R-R interval time series data were collected in a supine position.
  • Quantification of HRF metrics including percentage of inflection points (PIP) and word-based inflections (W0-W3, WH, WS, WM).

Main Results:

  • T2DM patients showed significantly higher PIP, WS, WM, and W3 compared to controls (p < 0.05).
  • Lower WH and W1 were observed in the T2DM group.
  • Moderate positive correlation between WH and HRV indices (RMSSD, HF); moderate negative correlation between WS, WM and HRV indices.

Conclusions:

  • T2DM is characterized by increased heart rate fragmentation patterns.
  • Specific HRF metrics, particularly those grouped by inflection type, demonstrate significant correlations with HRV indices.
  • The HRF approach shows promise for evaluating cardiac autonomic dysfunction in males with T2DM.
Abstract

Keywords:
Autonomic nervous systemHeart rate fragmentationHeart rate variabilitySymbolic dynamicType 2 diabetes mellitus

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