Mesoporous Silica Nanoparticles-Based Nanoplatforms: Basic Construction, Current State, and Emerging Applications in...

Area of Science:

• Nanotechnology
• Materials Science
• Biomedical Engineering

Background:

• Nanoparticles are increasingly utilized for medical diagnostics and therapeutics.
• Mesoporous silica nanoparticles (MSNs) possess unique physicochemical properties suitable for drug delivery and bioimaging.
• MSNs can be engineered to carry both therapeutic and imaging agents for multimodal cancer treatment.

Purpose of the Study:

• To review recent advancements in MSNs synthesis for drug delivery and smart response applications.
• To discuss the design of functional MSN materials for controlled anticancer drug release.
• To highlight the use of MSNs in bioimaging and as multifunctional delivery vehicles.

Main Methods:

• Overview of synthetic strategies for various MSN architectures (ordered, hollow, core-shell, dendritic, biodegradable).
• Discussion of functionalization techniques for controlled drug release mechanisms.
• Summary of recent research on MSN-based bioimaging applications.

Main Results:

• Various MSN structures can be synthesized for tailored drug delivery.
• Functionalized MSNs enable controlled and responsive drug release for enhanced anticancer therapy.
• MSNs demonstrate significant potential in multimodal bioimaging and drug delivery.

Conclusions:

• MSNs are versatile platforms for developing synergistic anticancer drug delivery systems.
• Future research should focus on optimizing MSN design for improved therapeutic efficacy and imaging capabilities.
• Continued development of MSNs will advance personalized cancer treatment strategies.