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Related Concept Videos

Teratogenicity01:07

Teratogenicity

2.6K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.6K

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Related Experiment Video

Updated: Aug 16, 2025

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay
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Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

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Neutropenia in Preterm Infants.

Gaetano Chirico1

  • 1Department of Neonatology and Neonatal Intensive Care, ASST Spedali Civili, Brescia, Italy.

Current Pediatric Reviews
|December 19, 2022
PubMed
Summary

Idiopathic neutropenia is common in preterm infants, increasing infection risk. Treatment with G-CSF is effective for severe cases (neutrophil count <500/μL for >2 days).

Area of Science:

  • Neonatal immunology
  • Hematology

Background:

  • Neonates have developing immune systems, making them vulnerable to infections.
  • Neutrophil deficiency is a key factor in neonatal susceptibility to infections.

Purpose of the Study:

  • To review the incidence and outcomes of unexplained neutropenia in preterm infants.

Main Methods:

  • Literature review of studies on neutropenia in preterm infants.

Main Results:

  • Idiopathic neutropenia, both early and late-onset, occurs frequently in premature infants.
  • Low neutrophil counts generally respond well to granulocyte-colony stimulating factor (G-CSF) treatment.

Conclusions:

  • Given the low risk of sepsis, especially in late-onset neutropenia, extensive diagnostics and G-CSF treatment should be reserved for severe cases.
Keywords:
Neutropeniaearly and late-onsethematopoietic growth factorsneonatalprematuritysepsis

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  • Severe cases are defined as neutrophil counts below 500/μL persisting for over two days.