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Exploiting lactic acid bacteria for colorectal cancer: a recent update
Yang Chen1,2, Bo Yang1,2,3, Jianxin Zhao1,2,3
1State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Critical Reviews in Food Science and Nutrition
|December 19, 2022
Summary
Lactic acid bacteria (LAB) show promise in preventing and treating colorectal cancer (CRC) by modulating gut health. Further research into LAB
Area of Science:
- Oncology
- Microbiology
- Gastroenterology
Background:
- Colorectal cancer (CRC) is a leading global cancer with significant mortality.
- Current treatments like chemotherapy and radiotherapy have severe side effects.
- There is an urgent need for novel, effective therapies for CRC prevention and treatment.
Purpose of the Study:
- To systematically review the incidence, mortality, risk factors, and molecular mechanisms of CRC.
- To summarize the anti-CRC roles of lactic acid bacteria (LAB) from animal and clinical studies.
- To critically analyze the mechanisms of LAB in alleviating CRC and identify research gaps.
Main Methods:
- Systematic literature review of CRC epidemiology and molecular mechanisms.
- Analysis of studies on probiotic interventions, specifically LAB, in CRC models.
- Critical evaluation of existing research on LAB's anti-CRC mechanisms and clinical efficacy.
Main Results:
- LAB can positively influence gut microbiota, immunity, and intestinal barrier function.
- Evidence from animal and clinical studies suggests LAB's potential in CRC management.
- LAB demonstrate diverse mechanisms against CRC, including immune modulation and anti-inflammatory effects.
Conclusions:
- LAB represent a promising avenue for CRC prevention and treatment.
- Current understanding of LAB's anti-CRC mechanisms requires further elucidation.
- Future research should focus on refining mechanisms and conducting robust clinical trials for LAB-based CRC therapies.
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