Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pixel Latency Measurements of Event Cameras.

IEEE transactions on instrumentation and measurement·2026
Same author

Single-particle studies of the effects of RNA-protein interactions on the self-assembly of RNA virus particles.

Proceedings of the National Academy of Sciences of the United States of America·2022
Same author

Dual-comb photoacoustic spectroscopy.

Nature communications·2020
Same journal

Segmentation-guided photon pooling enables robust single-cell analysis and fast fluorescence lifetime imaging microscopy.

Journal of biomedical optics·2026
Same journal

Method of spatial scanning of modulated laser radiation for outline imaging of interphalangeal joints.

Journal of biomedical optics·2026
Same journal

Multimodal optical imaging for the assessment of the teratogenic effects of ethanol on zebrafish development.

Journal of biomedical optics·2026
Same journal

Fluorescence properties of collagen types I-V: a comprehensive study of spectral and lifetime characteristics.

Journal of biomedical optics·2026
Same journal

Spectral dependence of lipofuscin fluorescence lifetimes revealed by FLIM with a superconducting nanowire single-photon detector.

Journal of biomedical optics·2026
Same journal

Building the future of biophotonics through experiential education and seasonal schools.

Journal of biomedical optics·2026
See all related articles

Related Experiment Video

Updated: Aug 16, 2025

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
07:01

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples

Published on: June 9, 2016

9.7K

Spatial frequency domain Mueller matrix imaging.

Joseph Chue-Sang1,2, Maritoni Litorja2, Aaron M Goldfain2

  • 1University of Maryland, Department of Chemistry and Biochemistry, College Park, Maryland, United States.

Journal of Biomedical Optics
|December 19, 2022
PubMed
Summary
This summary is machine-generated.

Combining Mueller matrix polarimetry (MMP) and spatial frequency domain imaging (SFDI) offers new ways to differentiate tissue structures. This novel optical imaging approach enhances contrast beyond individual methods.

Keywords:
Mueller matrixbrain tissuepolarimetryscatteringspatial frequency domain imagingtissue anisotropy

More Related Videos

Time Multiplexing Super Resolving Technique for Imaging from a Moving Platform
06:25

Time Multiplexing Super Resolving Technique for Imaging from a Moving Platform

Published on: February 12, 2014

8.5K
Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator
08:39

Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator

Published on: January 28, 2019

9.9K

Related Experiment Videos

Last Updated: Aug 16, 2025

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
07:01

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples

Published on: June 9, 2016

9.7K
Time Multiplexing Super Resolving Technique for Imaging from a Moving Platform
06:25

Time Multiplexing Super Resolving Technique for Imaging from a Moving Platform

Published on: February 12, 2014

8.5K
Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator
08:39

Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator

Published on: January 28, 2019

9.9K

Area of Science:

  • Optical imaging
  • Biomedical optics
  • Tissue optics

Background:

  • Mueller matrix polarimetry (MMP) differentiates tissue by structure alignment.
  • Spatial frequency domain imaging (SFDI) differentiates tissue by photon transport.
  • MMP and SFDI effects are related, suggesting synergistic potential.

Purpose of the Study:

  • To develop an instrument combining MMP and SFDI.
  • To test if combined MMP and SFDI enhances contrast in reflection mode.
  • To explore new contrast mechanisms for tissue differentiation.

Main Methods:

  • Constructed a combined MMP and SFDI instrument using liquid crystal polarization control, a DLP projector for patterned illumination, and a digital camera.
  • Performed theoretical analysis of the SFD Mueller matrix, noting its complex-valued nature.
  • Acquired images from tissue phantoms and biological tissues (cerebellum, thalamus, cerebrum).

Main Results:

  • Distinguished singly scattered, few scattered, and diffusely scattered photon paths in investigated samples.
  • Observed that combined imaging yields additional spatial frequency phase information.
  • Highlighted photon paths with few scattering events using the combined modality.

Conclusions:

  • The combination of MMP and SFDI provides novel contrast mechanisms.
  • This integrated approach offers enhanced tissue differentiation capabilities.
  • The combined modality reveals information not accessible by MMP or SFDI alone.