Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

855
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
855
UV–Vis Spectroscopy: Woodward–Fieser Rules01:29

UV–Vis Spectroscopy: Woodward–Fieser Rules

25.0K
UV–Visible absorption spectra of conjugated dienes arise from the lowest energy π → π* transitions. The light-absorbing part of the molecule is called the chromophore, and the substituents directly attached to the chromophore are called auxochromes. A strong correlation exists between the absorption maxima, λmax, and the structure of a conjugated π system. The Woodward–Fieser rules predict the value of λmax for a given...
25.0K
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry01:28

Diels–Alder Reaction Forming Cyclic Products: Stereochemistry

3.9K
The Diels–Alder reaction is one of the robust methods for synthesizing unsaturated six-membered rings. The reaction involves a concerted cyclic movement of six π electrons: four π electrons from the diene and two π electrons from the dienophile.
3.9K
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

2.0K
Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthetic study toward vibralactone.

Beilstein journal of organic chemistry·2025
Same author

A Synthesis of the Carbon Skeleton of Erectcyanthin C.

Organic letters·2025
Same author

Synthesis of the tricyclic skeleton of aberrarone.

Organic & biomolecular chemistry·2025
Same author

Total Synthesis of (+)-Ansatrienol K.

The Journal of organic chemistry·2025
Same author

Total synthesis and target identification of marine cyclopiane diterpenes.

Nature communications·2024
Same author

Asymmetric Synthesis of Scillascillin-Type Homoisoflavonoid.

Organic letters·2024

Related Experiment Video

Updated: Aug 16, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

9.9K

Synthetic study toward the diterpenoid aberrarone.

Liang Shi1, Zhiyu Gao1, Yiqing Li1

  • 1Department Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China.

Beilstein Journal of Organic Chemistry
|December 19, 2022
PubMed
Summary

Researchers report a new synthesis for aberrarone, an antimalarial diterpenoid. This approach utilizes Nagata reagent and gold catalysis to build the complex tetracyclic structure, aiding in the development of new antimalarial drugs.

Keywords:
C–H insertionPauson–Khandaberraronegoldtotal synthesis

More Related Videos

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
11:45

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Published on: August 22, 2018

8.5K
Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
11:04

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

3.1K

Related Experiment Videos

Last Updated: Aug 16, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

9.9K
Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
11:45

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Published on: August 22, 2018

8.5K
Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
11:04

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

3.1K

Area of Science:

  • Organic Chemistry
  • Natural Product Synthesis
  • Medicinal Chemistry

Background:

  • Aberraconone is a complex diterpenoid natural product with demonstrated antimalarial activity.
  • The intricate tetracyclic structure of aberrarone presents a significant synthetic challenge.
  • Developing efficient synthetic routes is crucial for accessing and studying potential antimalarial compounds.

Purpose of the Study:

  • To report a novel synthetic approach to the antimalarial natural product aberrarone.
  • To establish a stereoselective synthesis of the 6-5-5 tricyclic core of aberrarone.
  • To demonstrate the utility of specific reagents and catalytic methods in constructing complex molecular architectures.

Main Methods:

  • Stereoselective construction of the 6-5-5 tricyclic skeleton.
  • Utilization of the Nagata reagent for the formation of all-carbon quaternary centers at C1.
  • Gold-catalyzed intramolecular C-H insertion for cyclopentenone ring formation.

Main Results:

  • Successful synthesis of a tetracyclic diterpenoid natural product, aberrarone.
  • Efficient and stereoselective creation of the challenging 6-5-5 tricyclic core.
  • Demonstration of key bond formations, including quaternary centers and cyclopentenone rings.

Conclusions:

  • The reported synthetic strategy provides a viable route to aberrarone.
  • The methodology highlights the power of modern synthetic tools, like Nagata reagent and gold catalysis, in natural product synthesis.
  • This work contributes to the broader effort of synthesizing complex molecules with potential therapeutic applications, such as antimalarials.