Related Experiment Video
Updated: Aug 16, 2025
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
Frontotemporal phase lag index correlates with seizure severity in patients with temporal lobe epilepsy
Lingyan Mao1, Gaoxing Zheng1, Yang Cai1
1Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.
Objectives:
To find the brain network indicators correlated with the seizure severity in temporal lobe epilepsy (TLE) by graph theory analysis.
Methods:
We enrolled 151 patients with TLE and 36 age- and sex-matched controls with video-EEG monitoring. The 90-s interictal EEG data were acquired. We adopted a network analyzing pipeline based on graph theory to quantify and localize their functional networks, including weighted classical network, minimum spanning tree, community structure, and LORETA. The seizure severities were evaluated using the seizure frequency, drug-resistant epilepsy (DRE), and VA-2 scores.
Results:
Our network analysis pipeline showed ipsilateral frontotemporal activation in patients with TLE. The frontotemporal phase lag index (PLI) values increased in the theta band (4-7 Hz), which were elevated in patients with higher seizure severities (P < 0.05). Multivariate linear regression analysis showed that the VA-2 scores were independently correlated with frontotemporal PLI values in the theta band (β = 0.259, P = 0.001) and age of onset (β = -0.215, P = 0.007).
Significance:
This study illustrated that the frontotemporal PLI in the theta band independently correlated with seizure severity in patients with TLE. Our network analysis provided an accessible approach to guide the treatment strategy in routine clinical practice.
More Related Videos
12:09Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
06:07Construction of Local Field Potential Microelectrodes for in vivo Recordings from Multiple Brain Structures Simultaneously
Published on: March 14, 2022
Related Concept Videos
01:13Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
01:24Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...