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Extra-Articular Manifestations in Patients with Ankylosing Spondylitis: Baseline Characteristics from the RBSMR Study
Najlae El Ouardi1, Julien H Djossou1, Laila Taoubane1
1Department of Rheumatology, Military Hospital Mohammed V, Ibn Sina University Hospital, Rabat, Morocco.
Mediterranean Journal of Rheumatology
|December 19, 2022
Summary
Acute anterior uveitis (AAU) is the most common extra-articular manifestation (EAM) in ankylosing spondylitis (AS) patients in Morocco. Family history of spondyloarthritis is a significant risk factor for developing AAU in AS patients.
Area of Science:
- Rheumatology
- Ophthalmology
- Gastroenterology
Background:
- Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
- Extra-articular manifestations (EAMs) such as acute anterior uveitis (AAU), psoriasis, and inflammatory bowel disease (IBD) are common in AS patients.
- Understanding the prevalence and risk factors of EAMs is crucial for comprehensive patient management.
Purpose of the Study:
- To determine the prevalence of AAU, psoriasis, and IBD in Moroccan AS patients.
- To analyze risk factors associated with these EAMs.
- To compare EAM prevalence in AS patients with and without peripheral arthritis.
Main Methods:
- A cross-sectional, multicenter study utilizing the Moroccan registry of biological therapies in rheumatic diseases (RBSMR) database.
- Inclusion of 170 AS patients.
- Calculation of incidence rates for AAU, psoriasis, and IBD, followed by risk factor analysis.
Main Results:
- The prevalence of EAMs in AS patients was 13.5% for AAU, 4.7% for psoriasis, and 11.2% for IBD.
- No significant difference in EAM prevalence was observed between AS patients with and without peripheral arthritis.
- AAU was the most frequent EAM and was significantly associated with a family history of spondyloarthritis (OR=7.21).
Conclusions:
- Acute anterior uveitis (AAU) is the predominant EAM in AS patients within the Moroccan RBSMR cohort.
- A positive family history of spondyloarthritis is a key risk factor associated with AAU in AS.
Keywords:
acute anterior uveitisankylosing spondylitisextra-articular manifestationsinflammatory bowel diseasepsoriasisMore Related Videos
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