Related Experiment Video

Updated: Aug 16, 2025

Tissue Engineering of the Intestine in a Murine Model
08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

15.0K

Endoscopic treatment of intussusception due to small intestine polyps in patients with Peutz-Jeghers Syndrome

Kunihiko Oguro1, Hirotsugu Sakamoto1, Tomonori Yano1

  • 1Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.

Endoscopy International Open
|December 19, 2022
PubMed

Insights

Endoscopic treatment using double-balloon endoscopy (DBE) is a feasible option for intussusception caused by polyps in Peutz-Jeghers syndrome patients, successfully avoiding surgery in most cases. This minimally invasive approach achieved high success rates, offering a safe alternative to laparotomy.

Area of Science:

  • Gastroenterology
  • Surgical Innovation

Background:

  • Intussusception in Peutz-Jeghers syndrome patients typically necessitates surgical intervention (laparotomy).
  • Previous reports suggest successful endoscopic reduction of intussusception using double-balloon endoscopy (DBE).

Purpose of the Study:

  • To assess the feasibility and success rate of endoscopic treatment for intussusception in Peutz-Jeghers syndrome patients.
  • To evaluate the potential of endoscopic interventions to replace laparotomy.

Main Methods:

  • Retrospective review of patients with Peutz-Jeghers syndrome who underwent DBE for intussusception due to small intestine polyps (January 2004 - June 2020).
  • Analysis of endoscopic reduction, resection, or ischemic polypectomy procedures.
  • Evaluation of per-site and per-patient success rates and complications.

Main Results:

  • Twenty-seven DBE procedures were performed on 19 patients, addressing 25 intussusception sites.
  • Endoscopic treatment (reduction, resection, or polypectomy) was successful at 24 out of 25 sites (96%).
  • Per-patient success rate was 95% (18/19), with only one case requiring surgery. Mild complications included pancreatitis and post-procedure intussusception, managed non-operatively.

Conclusions:

  • Endoscopic treatment of intussusception is a feasible and effective strategy for patients with Peutz-Jeghers syndrome.
  • DBE offers a minimally invasive alternative to laparotomy, achieving high success rates.
  • Endoscopic interventions can significantly reduce the need for surgical management in this patient population.

More Related Videos

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors05:16

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors

Published on: February 19, 2022

6.0K

Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
186
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
142
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
148
Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
381
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
283
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
252