Modulation of natural killer cell activity by tamoxifen in stage I post-menopausal breast cancer
J Berry1, B J Green, D S Matheson
1Tom Baker Cancer Centre, Calgary, Alberta, Canada.
European Journal of Cancer & Clinical Oncology
|May 1, 1987
Abstract:
Tamoxifen, an antiestrogen which competes for the estrogen receptor, modulates natural killer cell activity in vivo. Seventeen post-menopausal stage I breast cancer patients received tamoxifen for 1 month and a statistically significant increase in NK activity was demonstrated (P = 0.0005). There was a small incremental shift in the number of Leu-11b positive cells. These data demonstrate that tamoxifen functions as a biological response modifier.


