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Thyroid function in patients with breast cancer.

B Rasmusson1, U Feldt-Rasmussen, L Hegedüs

  • 1Department of Oncology R and Endocrinology F, Herlev University Hospital, Denmark.

European Journal of Cancer & Clinical Oncology
|May 1, 1987
PubMed
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Women with breast cancer show a higher frequency of thyroid autoantibodies, even when thyroid function is normal. This suggests a potential link between breast cancer and autoimmune thyroid disease.

Area of Science:

  • Endocrinology
  • Oncology
  • Immunology

Background:

  • Breast cancer is a significant health concern.
  • Autoimmune thyroid diseases are common and involve immune system dysfunction.
  • The relationship between breast cancer and thyroid autoimmunity requires further investigation.

Purpose of the Study:

  • To investigate thyroid function and autoimmunity in patients with breast cancer.
  • To compare thyroid antibody prevalence in breast cancer patients versus healthy controls.
  • To explore potential associations between breast cancer and autoimmune thyroid conditions.

Main Methods:

  • Evaluated thyroid function in 58 breast cancer patients and compared with age-matched healthy controls.
  • Measured various thyroid antibodies, including thyroid stimulating antibodies, thyroglobulin antibodies, and microsomal antibodies.

Related Experiment Videos

  • Assessed serum levels of thyroid hormones (triiodothyronine, thyroxine) and thyroid stimulating hormone.

    • Main Results:

    • 50% of breast cancer patients had detectable thyroid antibodies, compared to controls.
    • Increased prevalence of thyroglobulin and microsomal antibodies was observed in breast cancer patients (P < 0.05).
    • No significant differences in thyroid hormone levels or thyroid stimulating hormone were found between groups.

    Conclusions:

    • Euthyroid breast cancer patients exhibit a higher frequency of thyroid autoantibodies.
    • Findings suggest a potential association between breast cancer and autoimmune thyroid disease.
    • Further research is warranted to elucidate the underlying mechanisms connecting these conditions.