Enhancing bioactivity and stability of polymer-based material-tissue interface through coupling multiscale...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Biocompatibility

Background:

• Stable and bioactive material-tissue interfaces (MTFs) are crucial for biomaterials in wound healing, drug delivery, and tissue engineering.
• Current inorganic nanomaterials for enhancing polymer biomaterials face limitations in stability and biocompatibility.

Purpose of the Study:

• To enhance the bioactivity and stability of polymer-matrix bio-composites using atomically thin TiO2 nanosheets.
• To investigate the effect of TiO2 nanosheets on material-tissue interfacial interactions.

Main Methods:

• Modification of resin with TiO2 nanosheets.
• Evaluation of mechanical properties, hydrophilicity, and stability of the modified resin.
• In vitro assessment of human dental pulp stem cell adhesion, proliferation, and differentiation.
• Analysis of TiO2 nanosheets' interaction with demineralized dentinal collagen.

Main Results:

• TiO2 nanosheet modification improved resin's mechanical properties, hydrophilicity, and stability.
• The modified resin effectively stimulated human dental pulp stem cell adhesion, proliferation, and osteogenic/odontogenic differentiation.
• TiO2 nanosheets enhanced the interaction between demineralized dentinal collagen and the resin.

Conclusions:

• Coupling multiscale material-tissue interfacial interactions with TiO2 nanosheets significantly enhances biomaterial stability and bioactivity.
• This approach offers a method to improve MTFs by designing biocompatible materials at the sub-nanoscale for advanced biomedical applications.