Related Experiment Video

Updated: Aug 16, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.0K

β-lactam precision dosing in critically ill children: Current state and knowledge gaps

Sonya Tang Girdwood1,2,3, Kathryn Pavia4, Kelli Paice4

  • 1Division of Clinical Pharmacology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Frontiers in Pharmacology
|December 19, 2022
PubMed

Insights

Precision dosing of beta-lactam antibiotics in critically ill children is gaining interest but faces implementation barriers. Further research is needed to identify optimal patient groups and confirm improved outcomes for this pediatric population.

Area of Science:

  • Pediatric Critical Care Medicine
  • Pharmacology and Therapeutics
  • Infectious Diseases

Background:

  • Growing interest exists in therapeutic drug monitoring and model-informed precision dosing for beta-lactam antibiotics in critically ill patients, including children.
  • A position paper supports these efforts in critically ill adults, yet widespread adoption in pediatric populations remains limited.
  • Understanding beta-lactam pharmacokinetics and pharmacodynamics in critically ill children is crucial for optimizing treatment.

Purpose of the Study:

  • To review current knowledge on beta-lactam antibiotic pharmacokinetics and pharmacodynamics in critically ill children.
  • To identify knowledge gaps hindering the acceptance and implementation of precision dosing strategies in this patient group.
  • To highlight areas for future research to facilitate the adoption of precision dosing.

Main Methods:

  • Literature review focusing on pharmacokinetic and pharmacodynamic data of beta-lactam antibiotics in critically ill children.
  • Analysis of existing guidelines and position papers regarding therapeutic drug monitoring.
  • Identification and definition of knowledge gaps and barriers to implementation.

Main Results:

  • Current understanding of beta-lactam pharmacokinetics and pharmacodynamics in critically ill children is summarized.
  • Key knowledge gaps include lack of consensus on specific subpopulations benefiting most from precision dosing.
  • Uncertainty regarding the impact of precision dosing on clinical outcomes in pediatric critical care is a significant barrier.

Conclusions:

  • Implementation of precision dosing for beta-lactam antibiotics in critically ill children requires addressing identified knowledge gaps.
  • Further research is essential to establish consensus on target populations and demonstrate improved patient outcomes.
  • Closing these knowledge gaps will support the wider adoption of evidence-based precision dosing strategies.

Keywords:
beta-lactam antibioticscritically illpediatricspopulation pharmacokinetic modelsprecision dosing

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