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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Gastrointestinal microbiota: A predictor of COVID-19 severity?

Maria Adriana Neag1, Damiana-Maria Vulturar2, Diana Gherman3

  • 1Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca 400337, Romania.

World Journal of Gastroenterology
|December 19, 2022
PubMed

Insights

The gut-lung axis influences inflammation in COVID-19. Improving gut microbiota with nutraceuticals may help prevent or treat this respiratory illness.

Area of Science:

  • Microbiology
  • Immunology
  • Infectious Diseases

Background:

  • Coronavirus disease 2019 (COVID-19) poses global health challenges, with severity influenced by comorbidities and age.
  • The gut microbiota impacts respiratory health, and respiratory infections can alter gut microbial composition.
  • The gut-lung axis plays a role in modulating inflammatory responses.

Purpose of the Study:

  • To explore the relationship between gut microbiota and COVID-19.
  • To investigate the potential of modulating the gut-lung axis for COVID-19 management.

Main Methods:

  • Review of existing literature on the gut-lung axis and COVID-19.
  • Analysis of the role of gut microbiota in respiratory viral infections.
  • Exploration of nutraceutical interventions for gut microbiota modulation.

Main Results:

  • Gut microbiota composition influences respiratory disease severity in COVID-19.
  • The gut-lung axis is a key modulator of inflammation in COVID-19.
  • Nutraceuticals can improve gut microbiota diversity and composition.

Conclusions:

  • Modulating intestinal microbiota through nutraceutical agents shows promise for COVID-19 prophylaxis and treatment.
  • Targeting the gut-lung axis may offer a novel therapeutic strategy for managing COVID-19.
  • Further research into gut microbiota interventions for respiratory viral infections is warranted.

Keywords:
COVID-19Gut microbiotaGut-lung axisNutraceuticalsProbioticsPrognostic biomarkers

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