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Recruitment in Acute Stroke Trials: Challenges and Potential Solutions
Joseph P Broderick1, Yasmin N Aziz1, Opeolu M Adeoye2
1University of Cincinnati Gardner Neuroscience Institute, OH (J.P.B., Y.N.A., P.K.).
Stroke
|December 19, 2022
Summary
Recruiting patients for acute stroke clinical trials is challenging. Solutions like expanding eligibility and using telemedicine can speed up enrollment for new stroke treatments.
Area of Science:
- Neurology
- Clinical Trials
- Stroke Research
Background:
- Randomized clinical trials have significantly advanced acute stroke therapy.
- Patient recruitment remains a major hurdle in acute stroke clinical trials, slowing therapeutic development.
Purpose of the Study:
- To identify challenges in recruiting patients for acute stroke trials.
- To propose solutions for accelerating enrollment and reducing costs in acute stroke research.
Main Methods:
- Review of challenges in acute stroke trial recruitment.
- Proposal of strategies including expanded inclusion criteria, telemedicine, and improved logistical support.
Main Results:
- Expanding inclusion criteria, assessed via epidemiological data, can boost enrollment and generalizability.
- Financial support for after-hours investigator availability and telemedicine training are key.
Conclusions:
- Implementing proposed solutions can expedite the identification of new acute stroke treatments.
- Addressing recruitment barriers is crucial for timely clinical benefit to acute stroke patients.
