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Correlation analysis in a set of X-benzyltrimethylammonium derivatives with antimuscarinic activity
M De Amici1, C De Micheli, P Pratesi
1Istituto di Chimica Farmaceutica, Università di Milano, Italy.
Abstract:
The results of a pharmacological investigation on a series of meta-substituted benzyltrimethylammonium salts possessing an antimuscarinic activity are reported. Correlative analysis shows that the pharmacodynamic activity is a function of the hydrophobic-lipophilic parameter associated with the substituent.