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[Synthesis and antiplatelet aggregating activity of several thiopyranylidene ketones and benzylidene indanones]
M Varache-Beranger1, A Nuhrich, G Devaux
1Laboratoire de Pharmacie Chimique et Chimie Thérapeutique, Université de Bordeaux II, France.
Il Farmaco; Edizione Scientifica
|June 1, 1987
Abstract:
Some new aryl thiopyranylidene ketones and benzylidene indanones with various substituents on the benzene ring were synthesized and their inhibitory activities in vitro on human platelet aggregation were assayed. The 2-[(2,5-dimethoxyphenyl)methylene] indan-1-one is the most potent inhibitor (about seventeen times more active than aspirin, against arachidonic acid, and twenty four times against collagen).