Related Experiment Video
Updated: Aug 4, 2026

09:01
Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation
Published on: October 15, 2021
7.8K
Intracranial haemorrhage and falls: cause or effect?
Lauren Vrbanic1, Ciara Hunt2, Maeve Cooney2
1School of Medicine, Trinity College Dublin, Dublin, Ireland.
Irish Journal of Medical Science
|December 19, 2022
Summary
Determining if intracranial hemorrhage caused or resulted from a fall is challenging. A neuropathologic examination is crucial for analyzing fatal falls with intracranial hemorrhage.
Area of Science:
- Neuropathology
- Forensic Medicine
- Autopsy Practice
Background:
- Distinguishing the cause of intracranial hemorrhage in relation to falls is a persistent challenge in forensic pathology.
- Autopsy reports often lack definitive conclusions regarding the causal link between falls and intracranial bleeding.
Purpose of the Study:
- To investigate the relationship between falls and intracranial hemorrhage in autopsy cases.
- To determine the incidence and characteristics of intracranial hemorrhage in individuals with a history of falls.
Main Methods:
- Retrospective analysis of 2,126 autopsy reports from 2009-2018.
- Focused examination of 226 cases with a history of falls, including comprehensive post-mortem neuropathologic assessment.
Main Results:
- Intracranial hemorrhage was present in 79% of fall cases (175/226).
- Traumatic intracranial hemorrhage (77%) was more common than spontaneous (23%).
- Falls from standing height were the most frequent cause of traumatic hemorrhage, with cerebral contusions and subdural hemorrhages being prevalent.
Conclusions:
- A thorough neuropathologic examination is essential for accurately analyzing fatal falls involving intracranial hemorrhage.
- Integrating neuropathologic findings into the overall death investigation improves the understanding of fall-related fatalities.
Related Concept Videos
Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Traumatic Brain Injury l: Introduction
DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
Increased Intracranial Pressure l: Introduction
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Increased Intracranial Pressure ll: Pathophysiology
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Cerebral Edema ll: Pathophysiology
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

