[Protein CD133 as a tumor stem cell marker].

Area of Science:

• Cellular biology
• Oncology
• Biochemistry

Background:

• The CD133 protein is a large transmembrane glycoprotein with an incompletely understood cellular function.
• Despite its unclear role, CD133 is associated with neoplastic transformation and cancer progression.
• This review focuses on CD133's structure, expression, interactions, and presence in malignant cells.

Approach:

• Comprehensive literature review of existing data on the CD133 protein.
• Analysis of CD133's structure, gene expression regulation, and molecular interactions.
• Examination of CD133's representation in various malignant cell types.

Key Points:

• CD133 protein's structure and expression regulation are crucial for understanding its function.
• Molecular interactions of CD133 provide insights into its role in cell signaling and transformation.
• CD133 is frequently found in cells that have undergone malignant transformation.

Conclusions:

• CD133 protein shows significant potential as a prognostic biomarker for survival in diverse solid tumors.
• CD133 may serve as a valuable diagnostic marker, particularly for glioma.
• Further research into CD133's functions could lead to novel cancer therapies.