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Using the IMEDS distributed database for epidemiological studies in type 2 diabetes mellitus.
Ting-Ying Huang1, Carla Rodriguez-Watson2, Tongtong Wang3
1Department of Population Medicine, Harvard Medical School, Boston, Massachusetts, USA.
BMJ Open Diabetes Research & Care
|December 19, 2022
Summary
The Innovation in Medical Evidence Development and Surveillance System Distributed Database (IMEDS-DD) database shows robust data for diabetes research, with patient characteristics similar to national benchmarks. This supports its use in pharmacoepidemiological studies.
Area of Science:
- Epidemiology
- Health Informatics
- Pharmacology
Background:
- The Innovation in Medical Evidence Development and Surveillance System Distributed Database (IMEDS-DD) is a valuable resource for real-world evidence generation.
- Assessing the quality and relevance of IMEDS-DD data is crucial for reliable diabetes research.
Purpose of the Study:
- To evaluate the data relevancy and quality of the IMEDS-DD for diabetes research.
- To compare the type 2 diabetes cohort within IMEDS-DD to the general type 2 diabetes population.
Main Methods:
- A retrospective study design was employed using the IMEDS-DD.
- Patient data from April 1, 2018, to March 31, 2019, were analyzed for type 2 diabetes and comorbidities.
- Characteristics and hemoglobin A1c (HbA1c) values were compared to national benchmarks.
Main Results:
- Type 2 diabetes prevalence in IMEDS-DD was 12.6%, with 4,146,772 patients identified.
- Patient demographics and comorbidities (hypertension, hyperlipidemia, obesity, cardiovascular disease, chronic kidney disease) closely mirrored national data.
- Metformin, sulfonylureas, and insulin were common treatments, though HbA1c values were recorded for less than half of patients.
Conclusions:
- The IMEDS-DD demonstrates strong data quality for key elements relevant to diabetes pharmacoepidemiological studies.
- Despite limitations in HbA1c data, the database is suitable for research on patient characteristics and healthcare utilization.
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