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Relationship between serum chloride and prognosis in non-ischaemic dilated cardiomyopathy: a large retrospective

Xinyi Li1, Xiaonan Zhang1, Yaoxin Liu1

  • 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, South China University of Technology, Guangzhou, China.

BMJ Open
|December 19, 2022
PubMed

Insights

Low serum chloride levels (hypochloremia) are linked to poor outcomes in elderly patients with non-ischaemic dilated cardiomyopathy (NIDCM). This finding highlights serum chloride as a key prognostic indicator for cardiovascular disease mortality.

Area of Science:

  • Cardiology
  • Clinical Chemistry
  • Internal Medicine

Background:

  • Serum chloride plays a role in neurohormonal pathways.
  • Hypochloremia may have prognostic value in cardiovascular diseases.
  • The prognostic significance of serum chloride in non-ischaemic dilated cardiomyopathy (NIDCM) requires further investigation.

Purpose of the Study:

  • To investigate the association between baseline serum chloride levels and clinical outcomes in elderly patients diagnosed with NIDCM.

Main Methods:

  • Retrospective study including 1088 elderly patients (≥60 years) with NIDCM.
  • Logistic regression and Receiver Operating Characteristic (ROC) curve analyses were performed.
  • Kaplan-Meier survival analysis assessed prognosis based on hypochloremia status.

Main Results:

  • Serum chloride was significantly associated with in-hospital death.
  • ROC analyses indicated excellent prognostic ability for both in-hospital and long-term mortality (AUCs 0.690 and 0.710).
  • Hypochloremia was linked to worse prognoses, and serum chloride independently predicted long-term death after adjustments.

Conclusions:

  • Serum chloride concentration serves as a prognostic indicator in elderly NIDCM patients.
  • Hypochloremia is significantly associated with adverse in-hospital and long-term outcomes.
  • Low serum chloride levels indicate a poorer prognosis in this patient population.
Abstract

Keywords:
adult cardiologycardiomyopathyheart failure

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