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Related Concept Videos

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
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The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
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Updated: Aug 16, 2025

Establishing a Mouse Model of Thin Endometrium
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Published on: November 1, 2024

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A decrease in endometrial thickness before embryo transfer is not associated with preterm birth and placenta-mediated

Pavan Gill1, Nir Melamed1, Jon Barrett2

  • 1Department of Obstetrics and Gynaecology, University of Toronto, Toronto Ontario, Canada.

Reproductive Biomedicine Online
|December 19, 2022
PubMed
Summary
This summary is machine-generated.

Endometrial compaction, a decrease in uterine lining thickness before embryo transfer, does not predict preterm birth or placenta-related pregnancy issues in IVF patients. This finding suggests endometrial thickness changes are not a reliable risk indicator for these complications.

Keywords:
Embryo transferEndometrial compactionEndometrial thicknessIVFPlacental complicationsPreeclampsia

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Area of Science:

  • Reproductive Endocrinology
  • Maternal-Fetal Medicine
  • In Vitro Fertilization (IVF)

Background:

  • Endometrial thickness is a key factor in successful embryo implantation.
  • The clinical significance of endometrial thinning (compaction) before embryo transfer remains unclear.
  • Investigating endometrial compaction's impact on pregnancy outcomes is crucial for IVF patient management.

Purpose of the Study:

  • To determine if endometrial compaction (≥10% decrease) before embryo transfer is associated with preterm birth.
  • To assess the relationship between endometrial compaction and placenta-mediated pregnancy complications in IVF pregnancies.

Main Methods:

  • Retrospective cohort study including 252 singleton live births after IVF embryo transfer (2016-2019).
  • Primary outcome: preterm birth (<37 weeks). Secondary outcomes: gestational hypertension, pre-eclampsia, intrauterine growth restriction, placental abruption.
  • Comparison of outcomes between patients with and without endometrial compaction, adjusting for confounders.

Main Results:

  • No significant difference in preterm birth rates between groups (13% with compaction vs. 6% without; P=0.09).
  • No significant difference in placenta-mediated complications (29.5% with compaction vs. 20% without; P=0.08).
  • Adjusted analysis confirmed no association between endometrial compaction and preterm birth (aOR 1.86, 95% CI 0.64-5.38).

Conclusions:

  • Endometrial compaction before embryo transfer is not a significant predictor of preterm birth in IVF pregnancies.
  • Endometrial compaction does not appear to increase the risk of placenta-mediated pregnancy complications.
  • Current findings suggest endometrial thickness decrease is not a clinically relevant prognostic factor for adverse pregnancy outcomes post-IVF.