Analyzing spatial distribution between ¹⁸F-fluorodeoxyglucose and ¹⁸F-boronophenylalanine positron emission...

¹⁸F-FDG PET is often utilized to determine BNCT selection due to the limited availability of ¹⁸F-BPA PET, which is performed by synthesizing ¹⁸F into the boron drug used for BNCT, although the uptake mechanisms between those are different. Additionally, only a few non-spatial point parameters, such as maximum SUV (SUV_max), have reported a correlation between those in previous studies. This study aimed to investigate the spatial accumulation pattern between those PET images in tumors, which would be expected to either show higher uptake on ¹⁸F-BPA PET or be utilized in clinical, to verify whether ¹⁸F-FDG PET could be used as a selection indicator for BNCT.

A total of 27 patients with 30 lesions (11 squamous cell carcinoma, 9 melanoma, and 10 rhabdomyosarcoma) who received ¹⁸F-FDG and ¹⁸F-BPA PET within 2 weeks were enrolled in this study. The ratio of metabolic tumor volumes (MTVs) to GTV, histogram indices (skewness/kurtosis), and the correlation of total lesion activity (TLA) and non-spatial point parameters (SUV_max, SUV_peak, SUV_min, maximum tumor-to-normal tissue ratio (T_max/N), and T_min/N) were evaluated. After local rigid registration between those images, distances of locations at SUV_max and the center of mass with MTVs on each image and similarity indices were also assessed along its coordinate.

In addition to SUV_max, SUV_peak, and T_max/N, significant correlations were found in TLA. The mean distance in SUV_max was [Formula: see text] and significantly longer than that in the center of mass with MTVs. The ratio of MTVs to GTV, skewness, and kurtosis were not significantly different. However, the similarities of MTVs were considerably low. The similarity indices of Dice similarity coefficient, Jaccard coefficient, and mean distance to agreement for MTV40 were [Formula: see text], [Formula: see text], and [Formula: see text] cm, respectively. Furthermore, it was worse in MTV50. In addition, spatial accumulation patterns varied in cancer types.

Spatial accumulation patterns in tumors showed low similarity between ¹⁸F-FDG and ¹⁸F-BPA PET, although the various non-spatial point parameters were correlated. In addition, the spatial accumulation patterns were considerably different in cancer types. Therefore, the selection for BNCT using ¹⁸F-FDG PET should be compared carefully with using ¹⁸F-FBPA PET.