Related Experiment Video
Updated: Aug 16, 2025
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Molecular mechanisms of ferroptosis and relevance to inflammation
Liyan Deng1, Shasha He2, Nuoqing Guo1
1The First Clinical College, Guangdong Medical University, Zhanjiang, 524023, Guangdong, China.
Introduction:
Inflammation is a defensive response of the organism to irritation which is manifested by redness, swelling, heat, pain and dysfunction. The inflammatory response underlies the role of various diseases. Ferroptosis, a unique modality of cell death, driven by iron-dependent lipid peroxidation, is regulated by multifarious cellular metabolic pathways, including redox homeostasis, iron processing and metabolism of lipids, as well as various signaling pathways associated with diseases. A growing body of evidence suggests that ferroptosis is involved in inflammatory response, and targeting ferroptosis has great prospects in preventing and treating inflammatory diseases.
Materials And Methods:
Relevant literatures on ferroptosis, inflammation, inflammatory factors and inflammatory diseases published from January 1, 2010 to now were searched in PubMed database.
Conclusion:
In this review, we summarize the regulatory mechanisms associated with ferroptosis, discuss the interaction between ferroptosis and inflammation, the role of mitochondria in inflammatory ferroptosis, and the role of targeting ferroptosis in inflammatory diseases. As more and more studies have confirmed the relationship between ferroptosis and inflammation in a wide range of organ damage and degeneration, drug induction and inhibition of ferroptosis has great potential in the treatment of immune and inflammatory diseases.
Insights
Ferroptosis, an iron-dependent cell death, is closely linked to inflammation and inflammatory diseases. Targeting ferroptosis offers promising therapeutic strategies for treating inflammatory conditions and organ damage.
Area of Science:
- Biochemistry
- Cell Biology
- Immunology
Background:
- Inflammation is a key biological response implicated in numerous diseases.
- Ferroptosis, a distinct form of cell death, is regulated by cellular metabolism and iron.
- Emerging evidence links ferroptosis to inflammatory processes.
Purpose of the Study:
- To review the regulatory mechanisms of ferroptosis.
- To elucidate the interplay between ferroptosis and inflammation.
- To explore the therapeutic potential of targeting ferroptosis in inflammatory diseases.
Main Methods:
- A comprehensive literature search was conducted on PubMed.
- Included studies published from January 1, 2010, to the present.
- Focused on ferroptosis, inflammation, inflammatory factors, and diseases.
Main Results:
- Ferroptosis is intricately connected with inflammatory responses.
- Mitochondria play a significant role in ferroptosis during inflammation.
- Targeting ferroptosis demonstrates potential in managing inflammatory diseases.
Conclusions:
- Ferroptosis is a significant factor in inflammatory diseases and organ damage.
- Modulating ferroptosis presents a promising therapeutic avenue.
- Further research into ferroptosis inhibitors and inducers is warranted for inflammatory and immune diseases.
Related Concept Videos
01:16Necrosis
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
01:31Regulation of the Unfolded Protein Response
01:30Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
02:26NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
01:38Inflammation
01:28Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...