Evaluation of integrin α_vβ₃-targeted imaging for predicting disease progression in patients with high-risk...

High-risk differentiated thyroid cancer (DTC) needs effective early prediction tools to improving clinical management and prognosis. This cohort study aimed to investigate the prognostic impact of ^99mTc-PEG₄-E[PEG₄-c(RGDfK)]₂ (^99mTc-3PRGD₂) SPECT/CT in high-risk DTC patients after initial radioactive iodine (RAI) therapy.

Thirty-three patients with high-risk DTC were prospectively recruited; all patients underwent total thyroidectomy and received ^99mTc-3PRGD₂ SPECT/CT before RAI ablation. Follow-up was done with serological and imaging studies. The correlation between ^99mTc-3PRGD₂ avidity and remission rate for initial RAI therapy was evaluated using logistic regression analysis. The prognostic value of ^99mTc-3PRGD₂ SPECT/CT was evaluated by Kaplan-Meier curve and Cox regression analysis.

^99mTc-3PRGD₂ avidity was significantly correlated with the efficacy of initial RAI ablation and an effective predictor for non-remission in high-risk DTC (OR = 9.36; 95% CI = 1.10-79.83; P = 0.041). ^99mTc-3PRGD₂ avidity was associated with poor prognosis in patients with high-risk DTC and an independent prognostic factor for shorter progression-free survival (PFS) (HR = 9.47; 95% CI = 1.08-83.20; P = 0.043). Survival analysis, which was performed between DTC patients with concordant (¹³¹I positive/^99mTc-3PRGD₂ positive) and discordant (¹³¹I negative/^99mTc-3PRGD₂ positive) lesions, indicated that patients with concordant lesions had significantly better PFS than those with discordant lesions (P = 0.022). Moreover, compared with repeated RAI, additional surgery or targeted therapy with multikinase inhibitors could lead to a higher rate of remission in ^99mTc-3PRGD₂-positive patients with progressive disease.

^99mTc-3PRGD₂ SPECT/CT is a useful modality in predicting progression of the disease after initial RAI and guiding further treatment in high-risk DTC patients.