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Updated: Aug 16, 2025

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
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Bromhexine and its fumarate salt: Crystal structures, Hirshfeld surfaces and dissolution study

Ya-An Zhang1, Cui-Min Yan2, Bai-Wang Sun2

  • 1School of Pharmaceutical and Chemical Engineering, Chengxian College, Southeast University, Nanjing 210088, PR China.

Journal of Molecular Structure
|December 20, 2022
PubMed
Summary

Bromhexine, an expectorant drug, was repurposed to improve its solubility and bioavailability using a multicomponent crystal strategy with fumaric acid. This new crystal form demonstrated enhanced thermal stability and water solubility compared to the original drug.

Keywords:
BromhexineCrystal structureHirshfeld surfaceMulticomponent crystalSaltSolubility

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