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Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
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Targeting RAD51-Mediated Homologous Recombination as a Treatment for Advanced Solid and Hematologic Malignancies:

Erica S Tsang1, Pamela N Munster1

  • 1Division of Hematology and Oncology, University of California San Francisco, San Francisco, CA, 94158, USA.

Oncotargets and Therapy
|December 20, 2022
PubMed

Insights

RAD51 protein is crucial for DNA repair and shows promise as a cancer biomarker and therapeutic target. Developing direct RAD51 inhibitors is challenging, but indirect inhibition strategies are being explored.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • RAD51 protein plays a key role in homologous recombination DNA repair.
  • RAD51 is a significant biomarker and therapeutic target in oncology.
  • Its predictive value is noted for platinum-based therapies and PARP inhibitors.

Purpose of the Study:

  • To review the development of RAD51 inhibitors.
  • To focus on novel molecules and clinical trials.
  • To explore the potential of indirect RAD51 inhibition.

Main Methods:

  • Review of in vitro and in vivo studies.
  • Analysis of ongoing clinical trials.
  • Literature search on RAD51 inhibitor development.

Main Results:

  • RAD51 is a validated predictive marker for certain cancer therapies.
  • Development of direct RAD51 inhibitors faces significant challenges.
  • Pharmacological indirect RAD51 inhibition shows clinical potential.

Conclusions:

  • RAD51 remains a critical target in cancer therapy.
  • Direct inhibition of RAD51 is difficult.
  • Indirect inhibition strategies offer a promising therapeutic avenue.
Keywords:
DNA damage repairHRDRAD51homologous recombination deficiency

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