Ischemia in aged brain
1Department of Pathochemistry and General Neurochemistry, University of Heidelberg, FRG.
Abstract:
A 15-min complete cerebral ischemia, and repetitive ischemic insults of 15-min duration each cause changes in brain cortical glucose and energy metabolism which are similar in quality but different in quantity. Abnormalities in glycolytic flux, lactate production, cessation of oxidation and energy production were found to be more pronounced with advancing age, thus indicating a reduced biological plasticity of the brain to meet emergency conditions. Repeatedly occurring ischemic insults may damage energy metabolism in particular.
Related Concept Videos
Ischemic Stroke l: Introduction
Ischemic Stroke ll: Pathophysiology
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Dementia l: Introduction


