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Published on: June 7, 2015
Injectable catechin-based supramolecular hydrogel for highly efficient application in HPV-associated OSCC
Shangxue Lei1,2, Xiaopei Hu1, Shaojuan Song1
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, Med-X Center for Materials, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P. R. China. xiaoping327@126.com.
A novel catechin-based hydrogel (CPBisoG) effectively treats human papillomavirus-associated oral squamous cell carcinoma (HPV+ OSCC). This injectable hydrogel overcomes catechin limitations, offering sustained release and selective inhibition for potential HPV+ OSCC management.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Oncology
Background:
- Catechins, natural polyphenols from green tea, possess anti-HPV and anti-tumor properties beneficial for HPV-associated oral squamous cell carcinoma (HPV+ OSCC).
- Clinical application of catechins is limited by poor bioavailability, short half-lives, and stability issues.
Purpose of the Study:
- To develop an injectable supramolecular hydrogel for enhanced catechin delivery.
- To overcome the limitations of catechins for effective HPV+ OSCC treatment.
Main Methods:
- Synthesized an injectable supramolecular hydrogel (CPBisoG) using catechin and isoguanosine via dynamic phenylborate diester bonds.
- Evaluated hydrogel properties including biodegradation, sustained release (up to 72 h in mice), stability, injectability, self-healing, biocompatibility, and biodegradability.
- Assessed therapeutic effects and selective inhibition against HPV+ OSCC cells *in vitro* and *in vivo*.
Main Results:
- The CPBisoG hydrogel demonstrated sustained release and biodegradation up to 72 hours in mice.
- The hydrogel exhibited excellent properties as a drug delivery platform: stable, injectable, self-healing, biocompatible, and biodegradable.
- CPBisoG showed significant therapeutic effects and selective inhibition against HPV+ OSCC cells *in vitro* and *in vivo*.
Conclusions:
- The catechin-based supramolecular hydrogel (CPBisoG) offers a promising strategy for sustained and effective topical treatment of HPV+ OSCC.
- This approach could be valuable for managing other human papillomavirus-associated diseases.
