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Related Experiment Video

Updated: Aug 16, 2025

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

Antibiotic Resistance and Microbiota Response.

Luigi Santacroce¹, Marina Di Domenico², Monica Montagnani³

¹Interdisciplinary Department of Medicine, Section of Microbiology and Virology, School of Medicine, University of Bari "Aldo Moro", Bari, Italy.

Current Pharmaceutical Design

|December 20, 2022

Summary

Antibiotic resistance is rising due to overuse, impacting gut microbiota. This review explores alternative treatments like probiotics and phage therapy to combat multi-drug resistant bacteria.

Keywords:

Antibiotics antibiotic resistance gut immunity gut microbiota multi-drug resistant bacteria probiotics

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Published on: November 18, 2022

Area of Science:

Microbiology
Immunology
Pharmacology

Background:

Antibiotics are crucial for treating bacterial infections but their overuse fuels multi-drug resistance.
Antibiotic use disrupts gut microbiota, compromising immune function and barrier integrity.
Reduced gut microbial diversity leads to metabolic changes and increased susceptibility to infections.

Approach:

This review details the mechanisms driving antibiotic resistance.
It highlights novel therapeutic strategies to overcome resistance.
Emphasis is placed on alternative treatments including microcins, prebiotics, probiotics, postbiotics, phage therapy, and fecal microbial transplantation.

Key Points:

Antibiotic resistance poses a significant global health threat.
Gut microbiota plays a vital role in host health and defense.
Disruption of gut microbiota by antibiotics exacerbates resistance and susceptibility.
Alternative therapies offer promising solutions to combat antibiotic resistance.

Conclusions:

Understanding the mechanisms of antibiotic resistance is critical.
Preserving and restoring gut microbiota is essential for host defense.
Exploring alternative treatments is imperative to address the challenge of multi-drug resistant bacteria.