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Granulocyte-dependent Autoantibody-induced Skin Blistering
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COVID-19 in Three Patients with Pemphigus
Layla Bendaoud1, Iyda Elfaqyr2, Ouafa Hocar2
1Department of Dermatology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Cadi Ayyad University, Marrakech, Morocco; laylabendaoud@gmail.com.
Skinmed
|December 20, 2022
Summary
Three patients with pemphigus on immunosuppressive therapy contracted COVID-19. This case series highlights the risks of SARS-CoV-2 infection in immunocompromised individuals with autoimmune diseases.
Area of Science:
- Immunology
- Infectious Diseases
- Dermatology
Background:
- COVID-19, caused by SARS-CoV-2, presents with varied severity.
- Healthcare professionals face challenges prescribing immunosuppressants for autoimmune conditions like pemphigus during the pandemic.
- Pemphigus is a chronic autoimmune blistering disease requiring immunosuppressive treatment.
Observation:
- Three patients diagnosed with pemphigus were undergoing immunosuppressive therapy.
- These patients subsequently developed SARS-CoV-2 infection.
Findings:
- The study reports on three pemphigus patients who contracted COVID-19 while on immunosuppressive treatment.
- This observation underscores the vulnerability of patients with autoimmune pathologies to SARS-CoV-2.
Implications:
- This case series emphasizes the need for careful management and monitoring of immunosuppressed pemphigus patients during the COVID-19 pandemic.
- Further research is warranted to understand the specific risks and outcomes for this patient population.
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