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Wound Infection Detection Using a Rapid Biomarker
Soheila S Kordestani1, Fahimeh S Mohammadi, Maryam Noordadi
1Soheila S. Kordestani, PhD, is Associate Professor, Department of Biomedical Engineering, Amirkabir University of Technology, and Managing Director, ChitoTech Inc, Tehran, Iran. Also at ChitoTech Inc, Fahimeh S. Mohammadi, MSc; Maryam Noordadi, MSc; Fatemeh Rezaee, MSc; and Fatemeh Fayyazbakhsh, MSc, are Research and Development Experts.
A new diagnostic biomarker effectively detects wound infections with high accuracy. This rapid, point-of-care test aids timely treatment and improves patient outcomes in wound care.
Area of Science:
- Biomarker development
- Diagnostic technology
- Wound care research
Background:
- Wound infection diagnosis is critical for effective healing.
- Gelatinases are key biomolecules overexpressed during wound infection.
- Rapid detection of wound infection is essential for timely treatment.
Purpose of the Study:
- To assess a novel point-of-care diagnostic biomarker for wound infection.
- To evaluate the biomarker's sensitivity to gelatinase overexpression.
- To determine the role of wound exudate pH in infection detection.
Main Methods:
- Biomarker safety was confirmed through cytotoxicity, irritation, and sensitization tests.
- The biomarker was validated in 198 patients with diverse wound types.
- Bacterial cultures and wound pH measurements served as controls.
Main Results:
- The diagnostic biomarker exhibited no adverse effects in patient testing.
- High performance metrics were achieved: 96.84% sensitivity, 97.5% specificity, 96.96% accuracy.
- Infected wounds showed higher pH values; nearly 80% of chronic wounds were infected.
Conclusions:
- The rapid diagnostic biomarker facilitates timely and efficient wound infection detection and treatment.
- Wound pH monitoring shows potential as an indicator for infection presence or absence.
- This technology can significantly aid healthcare providers in managing wound infections.
