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Updated: Aug 16, 2025
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Radiologic and Histologic Correlates of Early Interstitial Lung Changes in Explanted Lungs
Stijn E Verleden1, Arno Vanstapel1, Joseph Jacob1
1From the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).
None:
Background Interstitial lung abnormalities (ILAs) reflect imaging features on lung CT scans that are compatible with (early) interstitial lung disease. Despite accumulating evidence regarding the incidence, risk factors, and prognosis of ILAs, the histopathologic correlates of ILAs remain elusive. Purpose To determine the correlation between radiologic and histopathologic findings in CT-defined ILAs in human lung explants. Materials and Methods Explanted lungs or lobes from participants with radiologically documented ILAs were prospectively collected from 2010 to 2021. These specimens were air-inflated, frozen, and scanned with CT and micro-CT (spatial resolution of 0.7 mm and 90 microm, respectively). Subsequently, the lungs were cut and sampled with core biopsies. At least five samples per lung underwent micro-CT and subsequent histopathologic assessment with semiquantitative remodeling scorings. Based on area-specific radiologic scoring, the association between radiologic and histopathologic findings was assessed. Results Eight lung explants from six donors (median age at explantation, 71 years [range, 60-83 years]; four men) were included (unused donor lungs, n = 4; pre-emptive lobectomy for oncologic indications, n = 2). Ex vivo CT demonstrated ground-glass opacification, reticulation, and bronchiectasis. Micro-CT and histopathologic examination demonstrated that lung abnormalities were frequently paraseptal and associated with fibrosis and lymphocytic inflammation. The histopathologic results showed varying degrees of fibrosis in areas that appeared normal on CT scans. Regions of reticulation on CT scans generally had greater fibrosis at histopathologic analysis. Vasculopathy and bronchiectasis were also often present at histopathologic examination of lungs with ILAs. Fully developed fibroblastic foci were rarely observed. Conclusion This study demonstrated direct histologic correlates of CT-defined interstitial lung abnormalities. © RSNA, 2022 Supplemental material is available for this article. See also the editorial by Jeudy in this issue.
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