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Updated: Aug 16, 2025

Synovial Fluid Analysis to Identify Osteoarthritis
Published on: October 20, 2022
Crystal arthropathies and osteoarthritis-where is the link?
Mohamed Jarraya1, Frank Roemer2,3, C Kent Kwoh4
1Department of Radiology, Massachusetts General Hospital, Harvard Medical School, YAW 6044, Boston, MA, 02114, USA. mjarraya@mgh.harvard.edu.
Abstract:
Osteoarthritis (OA) is one of the leading causes of disability worldwide. As our understanding of OA progressively has moved from a purely mechanical "wear and tear" concept toward a complex multi-tissue condition in which inflammation plays a central role, the possible role of crystal-induced inflammation in OA incidence and progression may be relevant. In addition to gout, which affects 4% of the US population, basic calcium phosphate and calcium pyrophosphate deposition both may induce joint inflammation and may play a role in pain in OA. This narrative review article discusses the possible mechanisms underlying the associations between crystal-induced arthropathies and OA, and the important implications of these for clinical practice and future research.
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