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Related Concept Videos

Introduction to Hemostasis01:05

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Related Experiment Video

Updated: Aug 16, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Peripheral Microneedle Patch for First-Aid Hemostasis.

Jungho Lee1, Sebin Park1, Phuong Thao Le2

  • 1Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, 37673, Republic of Korea.

Advanced Healthcare Materials
|December 20, 2022
PubMed
Summary
This summary is machine-generated.

A novel dissolving microneedle (MN) patch delivers hemostatic drugs to damaged capillaries without direct wound contact, preventing rebleeding. This peripheral MN (p-MN) patch offers a safer, site-selective approach for emergency hemostasis.

Keywords:
hemostasismicroneedlesperipheral drug deliverywound healing

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmacology

Background:

  • Microneedle (MN) patches offer efficient drug delivery but risk capillary damage in bleeding wounds.
  • Existing MN technology is unsuitable for direct application to open wounds due to invasiveness.
  • A need exists for minimally invasive hemostatic drug delivery systems for emergency wound care.

Purpose of the Study:

  • To develop a shelf-stable, dissolving microneedle patch for hemostatic drug delivery.
  • To establish a peripheral microneedle (p-MN) system for site-selective topical drug absorption in damaged capillaries.
  • To evaluate the safety and efficacy of the p-MN patch for preventing rebleeding.

Main Methods:

  • Histological examination of MN invasiveness using a rat liver bleeding model.
  • Quantification of skin penetration force to compare p-MN with conventional MN patches.
  • Systematic evaluation of hemostatic performance by measuring bleeding weight and time.
  • In vivo testing in heparin-pretreated Sprague-Dawley rats.

Main Results:

  • The p-MN patch demonstrated reduced invasiveness compared to conventional MNs.
  • Topical drug absorption via damaged capillaries was achieved by the p-MN system.
  • The p-MN patch significantly reduced bleeding weight and time in a rat model.
  • Superior hemostatic performance was observed in heparin-pretreated rats.

Conclusions:

  • A novel dissolving peripheral microneedle (p-MN) patch effectively delivers hemostatic drugs to damaged capillaries.
  • The p-MN system provides a safe, site-selective, and minimally invasive method for emergency hemostasis.
  • This technology has the potential to prevent rebleeding in critical wound situations.