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Premature centromere division (PCD): a dominantly inherited cytogenetic anomaly
1Institute of Human Genetics, Medical Faculty, Free University, Amsterdam, The Netherlands.
Human Genetics
|October 1, 1987
Abstract:
We describe a family with an increased frequency of cells with premature centromere division (PCD) of all chromosomes in four phenotypically normal individuals. This familial PCD phenomenon is apparently different from the well-described PCD of the X chromosome and from the centromere splitting in cells of patients with Roberts syndrome. Implications for genetic counseling are discussed.