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Updated: Aug 16, 2025
07:35
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
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Emerging Tests for Noninvasive Colorectal Cancer Screening
Marina Hanna1, Neelendu Dey2, William M Grady3
1Department of Medicine, University of Washington, Seattle, Washington.
Summary
Colorectal cancer (CRC) screening is crucial for early detection and mortality reduction. Novel blood, stool, and microbiome tests show promise for improving compliance and effectiveness in CRC screening.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Colorectal cancer (CRC) is a leading cause of cancer death globally.
- Current screening methods have limitations in compliance and ideal performance.
- Screening is recommended for individuals aged 45 and older in the US.
Purpose of the Study:
- To review current colorectal cancer screening modalities.
- To discuss emerging CRC screening tests based on molecular, genetic, and epigenetic advances.
- To evaluate the potential of novel tests for clinical practice.
Main Methods:
- Review of current colorectal cancer screening methods.
- Discussion of novel screening technologies including blood-based assays (circulating tumor DNA, serum proteins), stool DNA/mRNA assays, and microbiome profiling.
- Analysis of supporting data for emerging tests.
Main Results:
- Current CRC screening methods are effective but face compliance challenges.
- Emerging tests leverage molecular biology, genetics, and epigenetics.
- Novel approaches include blood, stool, and microbiome-based assays.
Conclusions:
- Advances in molecular biology and technology are driving the development of new CRC screening tests.
- Emerging tests aim to overcome limitations of current methods, potentially improving early detection and patient compliance.
- Further data is needed to support the clinical integration of these promising novel screening strategies.
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