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Updated: Aug 16, 2025
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Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
Published on: July 29, 2013
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End-to-end testing for stereotactic radiotherapy including the development of a Multi-Modality phantom
Maya Shariff1, Johanna Grigo1, Siti Masitho1
1Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany.
Zeitschrift Fur Medizinische Physik
|December 20, 2022
Summary
A 3D-printed phantom insert for stereotactic radiation therapy was developed and tested. It demonstrated superior performance in MR imaging and non-coplanar positioning compared to the original insert.
Area of Science:
- Medical Physics
- Radiotherapy Technology
Background:
- End-to-end testing is crucial for validating radiotherapy workflows.
- Commercially available phantoms require inserts for specific testing scenarios.
Purpose of the Study:
- To design and 3D print a novel insert for a commercial end-to-end test phantom.
- To evaluate the performance of the new insert across various stereotactic radiation therapy (SRS, SBRT, FSRT, Multimet) workflows.
Main Methods:
- The study involved imaging (MR, CT), treatment planning, patient positioning, and irradiation procedures.
- Positioning accuracy was assessed using non-coplanar X-ray, kV- and MV-CBCT, and surface-guided systems.
- Dosimetric accuracy was measured using an ionization chamber on multiple linear accelerators, including dynamic tumor tracking for SBRT.
Main Results:
- The 3D-printed insert met CT specifications and enabled quantitative MR distortion analysis.
- Positioning accuracy with the new insert was < 1 mm/degree, significantly improving upon the original insert (> 3 mm) with challenging imaging systems.
- Point dose deviations were within 3% for SRS, FSRT, and SBRT, though Multimet plans showed >10% deviation due to measurement point selection.
Conclusions:
- The in-house manufactured 3D-printed insert performed effectively in all tested stereotactic radiation therapy end-to-end tests.
- Key advantages include enhanced MR image analysis, improved non-coplanar imaging compatibility, and suitability for dynamic tumor tracking.
