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Regulation of programmed cell death by Brd4
Jinfeng Hu1, Dun Pan2,1, Guo Li1
1Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, China.
Cell Death & Disease
|December 20, 2022
Summary
The epigenetic factor Brd4 regulates cancer cell growth and programmed cell death (PCD). Targeting Brd4 offers therapeutic potential for various diseases by modulating PCD pathways.
Area of Science:
- Molecular Biology
- Cell Biology
- Oncology
Background:
- Brd4 is an epigenetic factor crucial for cancer cell proliferation.
- Programmed cell death (PCD) is vital for tissue homeostasis and development.
- Dysregulation of PCD is implicated in cancer and other diseases.
Purpose of the Study:
- To review recent findings on Brd4's regulation of diverse PCD forms.
- To explore the therapeutic potential of targeting Brd4 in PCD-related diseases.
Main Methods:
- Literature review of studies on Brd4 and PCD.
- Analysis of Brd4's role in apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis.
Main Results:
- Brd4 actively regulates multiple forms of PCD beyond apoptosis.
- Brd4 inhibition impacts cancer cell growth and survival through PCD modulation.
- Different PCD pathways exhibit varied biological outcomes when regulated by Brd4.
Conclusions:
- Understanding Brd4-mediated PCD offers insights into disease pathophysiology.
- Targeting Brd4-regulated PCD presents novel therapeutic strategies for human diseases.
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