CO₂ fractional laser combined with triamcinolone acetonide injection for the hypertrophic scars: which is first?

The aim of this study is to investigate and analyze the effect of different application sequences of CO₂ fractional laser and triamcinolone acetonide injection on the application effect of hypertrophic scar in one operation. Patients with hypertrophic scars who received CO₂ lattice laser combined with triamcinolone acetonide injection from January 2021 to December 2022 were retrospectively analyzed. According to the different initial operations, they were divided into CO₂ FL-TA group and TA-CO₂ FL group. The Vancouver Scar Scale score and scar thickness of the two groups before and after treatment were analyzed. The complications occurred in the two groups during the treatment period. The clinical efficacy of the two groups before and after the treatment was calculated. Before treatment, there was no difference in scar thickness and VSS score between the two groups (P > 0.05). After treatment, the above indexes in CO₂ FL-TA group were significantly better than those in TA-CO₂ FL group (P < 0.05); the incidence of adverse reactions in CO₂ FL-TA group was 9.38%, which was significantly lower than that in TA-CO₂ FL group (18.75%) (P < 0.05); the total effective rate of CO₂ FL-TA group was 90.63%, which was significantly higher than that in TA-CO₂ FL group (65.63%) (P < 0.05). In the process of combined CO₂ fractional laser and triamcinolone acetonide injection in the treatment of hypertrophic scars, CO₂ fractional laser treatment first, and then triamcinolone acetonide injection can reduce the number of treatments, reduce the incidence of adverse reactions, and achieve more satisfactory treatment effect.