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Related Concept Videos

Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

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Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
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Protecting Groups for Aldehydes and Ketones: Introduction01:23

Protecting Groups for Aldehydes and Ketones: Introduction

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Protecting groups are compounds that can bind to a specific functional group in the presence of other functional groups to protect them from undesired chemical reactions. These compounds can selectively bind to particular functional groups and advance chemoselective reactions in polyfunctional systems (Figure 1). After the functional group has served its purpose, it is removed by reacting it with specific compounds.
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Reactions of Aldehydes and Ketones: Baeyer–Villiger Oxidation01:22

Reactions of Aldehydes and Ketones: Baeyer–Villiger Oxidation

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Baeyer–Villiger oxidation converts aldehydes to carboxylic acids and ketones to esters. The reaction uses peroxy acids or peracids and is often catalyzed by acid. The reaction is named after its pioneers, Adolf von Baeyer and Victor Villiger. The reaction is achieved by a wide range of peracids such as m-chloroperoxybenzoic acid (mCPBA), perbenzoic acid (C6H5COOOH), peracetic acid (CH3COOOH), hydrogen peroxide (H2O2), and tert-butyl hydroperoxide (t-BuOOH).
The carbonyl center is...
4.3K
Physical Properties of Alcohols and Phenols02:32

Physical Properties of Alcohols and Phenols

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Alcohols are organic compounds in which a hydroxy group is attached to a saturated carbon. Phenols are a class of alcohols containing a hydroxy group attached to an aromatic ring. The physical properties of the alcohols and phenols are influenced by hydrogen bonding due to the oxygen–hydrogen dipole in the hydroxy functional group and dispersion forces between alkyl or aryl regions of alcohol and phenol molecules.
Alcohols possess a higher boiling point than aliphatic hydrocarbons of...
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Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones01:24

Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones

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Acetals are formed by reacting two equivalents of alcohol with carbonyl compounds like aldehydes or ketones. Acetals are unaffected by bases, nucleophiles, oxidizing agents, and reducing agents. They serve as protecting groups for aldehydes and ketones. Acetals can be easily formed and also easily removed via mild acid hydrolysis.
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...
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Radical Chain-Growth Polymerization: Overview01:10

Radical Chain-Growth Polymerization: Overview

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Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
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Updated: Aug 16, 2025

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
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Functionalized aliphatic polyketones with germicide activity.

Esteban Araya-Hermosilla1, Paola Parlanti1, Mauro Gemmi1

  • 1Center for Materials Interfaces @SSSA, Istituto Italiano di Tecnologia Viale Rinaldo Piaggio 34 Pontedera (PI) 56025 Pisa Italy.

RSC Advances
|December 21, 2022
PubMed
Summary
This summary is machine-generated.

Novel germicidal paints were developed by incorporating quaternary ammonium compounds into polymer coatings. These innovative coatings demonstrate excellent antibacterial properties, effectively reducing pathogens on surfaces.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Surface Chemistry

Background:

  • Contaminated surfaces are a significant route for pathogen transmission, as highlighted by the COVID-19 pandemic.
  • Effective disinfectant surface treatments are crucial for public health and preventing disease spread.

Purpose of the Study:

  • To design and synthesize novel polymeric coatings with potent germicidal activity.
  • To functionalize a polyketone backbone with quaternary ammonium and sugar groups for enhanced surface disinfection and interaction.

Main Methods:

  • Aliphatic polyketone was functionalized using the Paal-Knorr reaction to introduce primary amine derivatives.
  • Quaternary ammonium and sugar moieties were incorporated into the polymer backbone.
  • Polymers were coated onto cellulose filter papers and checkerboard charts, with characterization by scanning electron microscopy.

Main Results:

  • The functionalized polymers exhibited excellent coating yield and substrate coverage.
  • Substrates coated with quaternary ammonium-containing polymers demonstrated significant bactericidal efficacy, achieving a 99% antibacterial rate and a logarithmic reduction of >3.
  • Polymers with increased hydrophobicity showed improved water resistance and retention on the substrate at neutral pH.

Conclusions:

  • Novel germicidal polymeric coatings incorporating quaternary ammonium compounds offer a promising solution for surface disinfection.
  • The developed coatings exhibit high antibacterial efficiency and good substrate adhesion, particularly for more hydrophobic variants.
  • This research contributes to the development of advanced materials for controlling pathogen spread on surfaces.