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Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

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Published on: October 13, 2023

Recent advances in micro-/nanostructure array integrated microfluidic devices for efficient separation of circulating

Hanyue Kang¹, Yuting Xiong¹, Liang Ma²

¹School of Materials Science and Engineering, Tongji University Shanghai 201804 China xiaobinxu@tongji.edu.cn.

|December 21, 2022

Summary

Microfluidic devices with micro-/nanostructure arrays enhance the capture of circulating tumor cells (CTCs) for liquid biopsies. These advanced techniques improve CTC separation efficiency, purity, and sensitivity for better cancer diagnostics.

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Area of Science:

Biomedical Engineering
Cancer Research
Nanotechnology

Background:

Circulating tumor cells (CTCs) in peripheral blood are crucial biomarkers for liquid biopsies, aiding in early cancer detection and monitoring.
Current CTC separation methods often compromise cell integrity, limiting comprehensive biological information acquisition.
The rarity and heterogeneity of CTCs necessitate the development of highly effective and sensitive separation techniques.

Purpose of the Study:

To review recent advancements in micro-/nanostructure array integrated microfluidic devices for CTC separation.
To discuss the mechanisms by which micro-/nanostructures enhance CTC capture efficiency, purity, and sensitivity.
To explore physical and chemical separation strategies utilizing these integrated microfluidic systems.

Main Methods:

Integration of micro-/nanostructure arrays (microrods, nanowires, 3D structures) with microfluidic chips.
Utilizing precise fluid control at the micron level for enhanced CTC separation.
Employing both physical property-based and biological property-based separation methods with modified capture probes.

Main Results:

Micro-/nanostructure arrays significantly improve CTC capture efficiency, purity, and sensitivity compared to traditional methods.
These structures offer increased biomolecule binding sites and unique fluid barrier effects.
The review categorizes separation into physical (structure-based) and chemical (probe-based) approaches.

Conclusions:

Micro-/nanostructure array integrated microfluidic devices represent a significant advancement in CTC separation technology.
These technologies hold great promise for improving liquid biopsy sensitivity and accuracy.
The development of these advanced separation tools is expected to revolutionize future disease diagnosis and monitoring.