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Related Experiment Video

Updated: Aug 16, 2025

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

A Rare Case of Rhabdomyolysis.

Francisco Pombo¹, Ana Raposo², Marta Dalila Martins¹

¹Internal Medicine, Centro Hospitalar do Tâmega e Sousa, Penafiel, PRT.

|December 21, 2022

Summary

This summary is machine-generated.

Rhabdomyolysis, a condition causing muscle breakdown and weakness, can stem from rare immune-mediated necrotizing myopathies. This case highlights seronegative IMNM

Keywords:

corticosteroids myalgia necrotizing myositis oral methotrexate paresis rhabdomyolysis

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Published on: August 23, 2024

Area of Science:

Neurology
Immunology
Pathology

Background:

Rhabdomyolysis involves muscle breakdown, elevated creatine kinase, and potential kidney injury.
Immune-mediated necrotizing myopathy (IMNM) is a rare inflammatory myopathy causing rhabdomyolysis.
IMNM subtypes include anti-HMGCR, anti-SRP, and seronegative forms with varying clinical features.

Observation:

A 67-year-old female presented with six weeks of thigh myalgia and weakness.
Laboratory results revealed significant rhabdomyolysis and acute kidney injury.
Diagnostic workup identified seronegative immune-mediated necrotizing myopathy.

Findings:

Seronegative IMNM was diagnosed in the patient.
Treatment involved corticosteroids and methotrexate.
The patient experienced marked clinical improvement following treatment.

Implications:

This case underscores the importance of recognizing seronegative IMNM as a cause of rhabdomyolysis.
Early diagnosis and immunosuppressive therapy can lead to significant recovery.
Further research into IMNM subtypes and treatment strategies is warranted.