Related Experiment Video

Updated: Aug 16, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

342

Association between the triglyceride-glucose index and albuminuria in hypertensive individuals

Yunfan Tian1, Jingyu Sun2, Ming Qiu1

  • 1Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|December 21, 2022
PubMed

Insights

The triglyceride-glucose (TyG) index is linked to increased albuminuria in hypertensive individuals. Higher TyG index levels correlate with a greater risk of this kidney damage marker in hypertension patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Syndrome

Background:

  • The triglyceride-glucose (TyG) index is a marker associated with vascular damage.
  • Albuminuria signifies hypertension-mediated organ damage and elevated cardiovascular disease (CVD) risk.
  • The relationship between the TyG index and albuminuria in hypertensive patients remains unclear.

Purpose of the Study:

  • To investigate the association between an elevated TyG index and albuminuria in a hypertensive population.
  • To determine if the TyG index can serve as a predictor for albuminuria in individuals with hypertension.

Main Methods:

  • A population-based study involving 789 hypertensive participants.
  • Logistic regression models were employed to analyze the association between TyG index quartiles and albuminuria.
  • Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to quantify the risk.

Main Results:

  • A significant positive association was found between the TyG index and albuminuria.
  • Participants in higher TyG index quartiles (II, III, IV) showed significantly increased odds of albuminuria compared to the lowest quartile.
  • The fully adjusted OR for the highest quartile (IV) was 3.46 (95% CI: 2.06-5.91).

Conclusions:

  • The TyG index is positively associated with albuminuria in hypertensive patients.
  • Elevated TyG index levels may indicate an increased risk of kidney damage in individuals with hypertension.
Abstract

Keywords:
The triglyceride-glucose indexalbuminuriaelderlyhypertensioninsulin resistance

More Related Videos

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

69.0K
Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method08:04

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

19.1K

Related Concept Videos

Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
258
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
18
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
311
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
645
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
33
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
23.9K